1
عمومی::
فشار خون شریانی
The effects of these vasoactive drugs on cerebral physiology are dependent on basal arterial blood pressure, the magnitude of the drug-induced arterial blood pressure changes, the status of the autoregulation mecha- nism, and the status of the BBB.
Ephedrine, although increasing arterial blood pressure to a similar extent as phenylephrine, did not reduce rSO2, presumably because of its ability to maintain cardiac output.
In human volunteers, a norepinephrine-induced increase in arterial blood pressure slightly reduced MCAfv and cerebral oxy- gen saturation (Sco2) and SjVo2.32 By contrast, although phenylephrine decreased rSO2, MCAfv was increased and SjVo2 was unchanged.33 These data have led to the question of whether phenylephrine and norepinephrine administration negatively impact cerebral oxygenation.
In the absence of direct measurement of brain tissue oxygen- ation, a modest reduction in Sco2 in the face of increas- ing arterial blood pressure cannot be taken as evidence of impairment of cerebral oxygenation.
However, the well-known effect of dexmedetomidine in decreas- ing arterial blood pressure merits careful consideration if used in patients who are critically dependent on collateral perfusion pressure, especially in the recovery phase of an anesthetic.
واژگان شبکه مترجمین ایران